Neutralizing monoclonal antibodies to hepatitis A virus: partial localization of a neutralizing antigenic site
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چکیده
منابع مشابه
Neutralizing monoclonal antibodies recognize antigenic variants among isolates of infectious hematopoietic necrosis virus
Neutralizing monoclonal antibodies were developed against strains of infectious hematopoietic necrosis virus (IHNV) from steelhead trout Salmo gajrdneri in the Deschutes River of Oregon, chinook salmon Oncorhynchus tshawytscha in the Sacramento h v e r of California, and rainbow trout Salmo gairdneri reared in the Hagerman Valley of Idaho. USA. These antibodies were tested for neutralization of...
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The humoral response to hepatitis C virus (HCV) may contribute to controlling infection. We previously isolated human monoclonal antibodies to conformational epitopes on the HCV E2 glycoprotein. Here, we report on their ability to inhibit infection by retroviral pseudoparticles incorporating a panel of full-length E1E2 clones representing the full spectrum of genotypes 1-6. We identified one an...
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Synthetic peptides have a successful record of immunological applications as models of continuous epitopes or immunogens capable of eliciting antibodies of predetermined specificity.1 The peptide approach has been crucial for the molecular dissection of protein antigens and has also resulted in useful applications, including peptide-based vaccines.2 The success of the methodology, however, tend...
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Ebola virus infections cause a deadly hemorrhagic disease for which no vaccines or therapeutics has received regulatory approval. Here we show isolation of three (Q206, Q314 and Q411) neutralizing monoclonal antibodies (mAbs) against the surface glycoprotein (GP) of Ebola virus identified in West Africa in 2014 through sequential immunization of Chinese rhesus macaques and antigen-specific sing...
متن کاملNeutralizing Antibodies and Pathogenesis of Hepatitis C Virus Infection
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The interplay between the virus and host innate and adaptive immune responses determines the outcome of infection. There is increasing evidence that host neutralizing responses play a relevant role in the resulting pathogenesis. Furthermore, viral evasion from host neutralizing antibodies has been revealed to...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1984
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.52.2.465-473.1984